This briefing provides an overview of the Department of Energy’s Genesis Mission, initiated by executive order in November 2025. It outlines the strategic vision to accelerate innovation and research in energy, discovery science and strengthen national security with the help of AI and next-generation research.
The briefing highlights the DOE’s 26 priority science and technology challenges, initial investments and the role of national labs in supporting the Gensis Mission objectives. In addition to AI, there are technology opportunities identified across data, compute, secure infrastructure, systems integration and emerging technologies.
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